CYTOKINE X

This Inflammatory cytokine X (undisclosed identity) is a key regulator with significant data supporting its role in multiple inflammatory diseases.

Nuevolution has identified first-in-class potent and selective small molecules against this target with confirmed inhibition of cytokine stimulation in a number of cell-based assays. We have obtained the first co-crystal structure of our small molecules binding this cytokine and are presently conducting structure-guided optimization.